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Tomoshige Kino Selected Research

Glucocorticoid Receptor Deficiency

1/2018Single Nucleotide Variations of the Human GR Gene Manifested as Pathologic Mutations or Polymorphisms.
1/2017AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.
2/2016Structural Analysis on the Pathologic Mutant Glucocorticoid Receptor Ligand-Binding Domains.
5/2014A novel point mutation of the human glucocorticoid receptor gene causes primary generalized glucocorticoid resistance through impaired interaction with the LXXLL motif of the p160 coactivators: dissociation of the transactivating and transreppressive activities.
4/2013A novel point mutation in the DNA-binding domain (DBD) of the human glucocorticoid receptor causes primary generalized glucocorticoid resistance by disrupting the hydrophobic structure of its DBD.
1/2013Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity.
10/2010Chrousos syndrome: a seminal report, a phylogenetic enigma and the clinical implications of glucocorticoid signalling changes.
5/2010A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain.
1/2009Identification of natural human glucocorticoid receptor (hGR) mutations or polymorphisms and their functional consequences at the hormone-receptor interaction level.
5/2008Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder.
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Tomoshige Kino Research Topics

Disease

22Glucocorticoid Receptor Deficiency
01/2018 - 04/2002
8Hypersensitivity (Allergy)
12/2015 - 12/2002
8Insulin Resistance
11/2013 - 06/2003
7Inflammation (Inflammations)
01/2024 - 01/2003
7Infections
01/2021 - 12/2002
6Acquired Immunodeficiency Syndrome (AIDS)
11/2023 - 12/2002
6Cushing Syndrome
05/2014 - 04/2002
6Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2013 - 06/2003
5Obesity
05/2013 - 06/2007
5Hyperandrogenism
10/2010 - 01/2004
4Lipodystrophy
09/2013 - 06/2003
4Fatigue
10/2009 - 04/2004
3Virus Diseases (Viral Diseases)
06/2021 - 05/2011
3Hypertension (High Blood Pressure)
08/2012 - 09/2002
3Atherosclerosis
10/2009 - 10/2004
2COVID-19
06/2021 - 01/2021
2Hyperaldosteronism (Conn Syndrome)
07/2013 - 08/2012
2Hyperuricemia
01/2013 - 01/2010
2Neurodegenerative Diseases (Neurodegenerative Disease)
05/2010 - 07/2007
2Type 2 Diabetes Mellitus (MODY)
10/2009 - 06/2007
2Essential Hypertension
10/2009 - 06/2007
2Pain (Aches)
10/2009 - 06/2007
2Osteoporosis
10/2009 - 06/2007
2Sleep Initiation and Maintenance Disorders (Insomnia)
10/2009 - 06/2007
1Hyponatremia
11/2023
1AIDS-Associated Nephropathy (HIV-Associated Nephropathy)
11/2023
1Respiratory Insufficiency (Respiratory Failure)
06/2021
1Human Influenza (Influenza)
06/2021
1Communicable Diseases (Infectious Diseases)
06/2021
1Sepsis (Septicemia)
06/2021
1Pneumonia (Pneumonitis)
06/2021
1Pathologic Processes
01/2020
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2017
1Mood Disorders (Mood Disorder)
01/2015
1Inborn Genetic Diseases (Disease, Hereditary)
05/2014
1HIV Infections (HIV Infection)
09/2013
1Chronic Renal Insufficiency
07/2013
1Overweight
05/2013
1Cardiovascular Diseases (Cardiovascular Disease)
10/2012
1Body Weight (Weight, Body)
09/2012
1Thyroid Hormone Resistance Syndrome (Thyroid Hormone Resistance)
08/2012
1Hepatocellular Carcinoma (Hepatoma)
01/2012
1Hypoglycemia (Reactive Hypoglycemia)
05/2010
1Hypokalemia
05/2010
1Starvation
02/2010
1Diabetic Nephropathies (Diabetic Nephropathy)
01/2010

Drug/Important Bio-Agent (IBA)

33GlucocorticoidsIBA
06/2021 - 06/2002
16Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
02/2016 - 06/2003
10Proteins (Proteins, Gene)FDA Link
06/2021 - 09/2002
9Hydrocortisone (Cortisol)FDA LinkGeneric
05/2014 - 04/2002
8MineralocorticoidsIBA
10/2010 - 04/2002
6Dexamethasone (Maxidex)FDA LinkGeneric
06/2021 - 04/2002
6SteroidsIBA
06/2021 - 09/2002
6LigandsIBA
05/2014 - 06/2002
5Messenger RNA (mRNA)IBA
05/2013 - 05/2009
4Insulin (Novolin)FDA Link
09/2012 - 06/2004
4AldosteroneIBA
08/2012 - 01/2004
4Adrenocorticotropic Hormone (ACTH)FDA Link
10/2010 - 04/2002
3vpr Gene ProductsIBA
11/2023 - 02/2008
3Amino AcidsFDA Link
01/2018 - 06/2002
3Hormones (Hormone)IBA
01/2015 - 06/2004
3CytokinesIBA
05/2013 - 08/2007
3glucocorticoid receptor alphaIBA
04/2006 - 04/2004
2SaltsIBA
11/2023 - 09/2002
2Transcription Factors (Transcription Factor)IBA
01/2020 - 04/2005
2Citric Acid (Citrate)FDA LinkGeneric
01/2013 - 01/2010
2Allopurinol (Remid)FDA LinkGeneric
01/2013 - 01/2010
2Uric Acid (Urate)IBA
01/2013 - 01/2010
2Xanthine OxidaseIBA
01/2013 - 01/2010
2Glucose (Dextrose)FDA LinkGeneric
09/2012 - 01/2010
2AndrogensIBA
08/2012 - 04/2002
2Cyclin-Dependent Kinase 5IBA
05/2010 - 07/2007
1ProstaglandinsIBA
01/2024
1SodiumIBA
01/2022
1AntibodiesIBA
01/2021
1Immunoglobulin G (IgG)IBA
01/2021
1VaccinesIBA
01/2021
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
01/2017
1Protein Kinases (Protein Kinase)IBA
11/2013
1Adenosine Monophosphate (AMP)IBA
11/2013
1DNA (Deoxyribonucleic Acid)IBA
04/2013
1Toll-Like Receptors (Toll-Like Receptor)IBA
01/2013
1Interleukin-10 (Interleukin 10)IBA
01/2013
1InterleukinsIBA
01/2013
1Malondialdehyde (Propanedial)IBA
09/2012
1AcidsIBA
08/2012
1PotassiumIBA
08/2012
1Phosphoenolpyruvate CarboxylaseIBA
01/2012
1Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA
01/2012
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
05/2011
1InterferonsIBA
05/2011
1Polymethyl Methacrylate (Sol)IBA
01/2011
1Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA
07/2010
1Furylfuramide (AF2)IBA
05/2010
1Arginine (L-Arginine)FDA Link
05/2010
1Untranslated RNA (Noncoding RNA)IBA
02/2010
1Angiotensin IIIBA
01/2010

Therapy/Procedure

2Therapeutics
09/2013 - 10/2004
1Critical Care (Surgical Intensive Care)
01/2021
1Adrenalectomy
07/2013